Study of spontaneous bold fluctuation in animal and human brains

Loading...
Thumbnail Image

Persistent link to this item

Statistics
View Statistics

Journal Title

Journal ISSN

Volume Title

Title

Study of spontaneous bold fluctuation in animal and human brains

Published Date

2010-09

Publisher

Type

Thesis or Dissertation

Abstract

Spontaneous blood-oxygen-level-dependent (BOLD) signals acquired at the resting state have recently been found to fluctuate coherently within many anatomically-connected and functionally-specific brain networks, and it may reflect an orderly organization of ongoing brain activity. Understanding this phenomenon may help us not only to understand some fundamental mechanisms of brain functions but also to find its applications in clinical field. However, the mechanisms underlying this phenomenon remains elusive, and even its neural origin is still controversial. This dissertation aimed to understand spontaneous BOLD fluctuation from its neurophysiological basis, its modulation under different brain states, and its role in brain functions. With five projects performed both on animals and humans, we have found that i) spontaneous BOLD fluctuation under deep burst-suppression anesthesia originates from underlying spontaneous neural activity, ii) spontaneous BOLD fluctuation is sensitive to changes in anesthesia depth, reflecting reorganization of ongoing brain activity at different consciousness level, iii) the resting-state visual network is spatially reorganized into activated and non-activated coherent network under continuous stimulation, and iv) the correlation strength within individuals' resting-state network can affect their evoked response to identical stimulations. These findings clearly support the functional significance of spontaneous BOLD fluctuation widely observed in animals and humans brain and provide new insights into its underlying mechanisms.

Description

University of Minnesota Ph.D. dissertation. September 2010. Major: Biomedical engineering. Advisor: Wei Chen. 1 computer file (PDF); ix, 176 pages.

Related to

Replaces

License

Collections

Series/Report Number

Funding information

Isbn identifier

Doi identifier

Previously Published Citation

Other identifiers

Suggested citation

Liu, Xiao. (2010). Study of spontaneous bold fluctuation in animal and human brains. Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/143300.

Content distributed via the University Digital Conservancy may be subject to additional license and use restrictions applied by the depositor. By using these files, users agree to the Terms of Use. Materials in the UDC may contain content that is disturbing and/or harmful. For more information, please see our statement on harmful content in digital repositories.