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Fear-Potentiated Startle Paradigm in Mice

Zimbel, Max
Demova, Jiva
2012-02-27
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https://hdl.handle.net/11299/121597
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Fear-Potentiated Startle Paradigm in Mice

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2012-02-27

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TUF1 is a novel neuropeptide highly concentrated in the amygdala, hippocampus, hypothalamus, and the endocrine tissue. Due to the high concentration in these regions, it is believed that TUF1 may play a role in stress regulation and fear-learning. Fear-learning is a form of Classical Conditioning. Fear is measured by Fear-Potentiated Startle (FPS). FPS is a valid and reliable method of measuring fear in rats. This study was conducted in the attempt to create a working FPS paradigm for mice in the Gewirtz Lab. After establishing this paradigm, we should be able to study the effects of TUF1 more efficiently using TUf1 knock-out mice.

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Faculty adviser: Prof. Jonathan Gewirtz

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UMTC Undergraduate Research Presentations and Papers (UROP)

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This project was sponsored by the Undergraduate Research Opportunities Program.

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Zimbel, Max; Demova, Jiva. (2012). Fear-Potentiated Startle Paradigm in Mice. Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/121597.

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