Platelet count and plateletcrit in Cavalier King Charles Spaniels and Greyhounds using the Advia 120/2120
2013-01
Loading...
View/Download File
Persistent link to this item
Statistics
View StatisticsJournal Title
Journal ISSN
Volume Title
Title
Platelet count and plateletcrit in Cavalier King Charles Spaniels and Greyhounds using the Advia 120/2120
Authors
Published Date
2013-01
Publisher
Type
Thesis or Dissertation
Abstract
Background: Models for the regulation of thrombopoiesis predict that platelet mass is the biologically regulated parameter, yet clinical evaluations are often based on platelet number. When there is concurrent thrombocytopenia and variation in platelet size, platelet count may poorly estimate total platelet mass, confounding clinical decision making.
Objective: We hypothesize that plateletcrit provides clinically important information when platelet number is an incomplete representation of platelet mass, such as in genetic macrothrombocytopenia.
Methods: We retrospectively compared platelet count and plateletcrits with general reference intervals for four groups of dogs: sick Cavalier King Charles Spaniels and Greyhounds that presented for non-hematopoietic disease to the University of Minnesota (Advia 2120) and Auburn University Teaching Hospitals (Advia 120) over a 3 year period.
Results: A canine plateletcrit reference interval of 0.129 – 0.403 % was established. None of the four sample groups were found to have significantly more individuals below the reference interval for plateletcit. For platelet count, only the Cavalier groups were found to have significantly more individuals below the reference interval than predicted.
Conclusion: Use of the plateletcrit as determined by the Advia 120/2120 appeared to avoid overestimation of low platelet mass in sick Cavalier Kind Charles Spaniels in a clinical setting. In contrast, the plateletcrit performed similarly to the platelet count in evaluation of platelet mass in sick Greyhounds. Evaluation of the plateletcrit should be considered in other conditions associated with increased mean platelet volume.
Description
University of Minnesota M.S. thesis. January 2013. Major: Clinical Laboratory Science. Advisor: Leslie C. Sharkey. 1 computer file (PDF); vi, 70 pages.
Related to
Replaces
License
Series/Report Number
Funding information
Isbn identifier
Doi identifier
Previously Published Citation
Suggested citation
Kelley, Jessica Anne. (2013). Platelet count and plateletcrit in Cavalier King Charles Spaniels and Greyhounds using the Advia 120/2120. Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/146409.
Content distributed via the University Digital Conservancy may be subject to additional license and use restrictions applied by the depositor. By using these files, users agree to the Terms of Use. Materials in the UDC may contain content that is disturbing and/or harmful. For more information, please see our statement on harmful content in digital repositories.