Cardiac repair using fibrin patch-based enhanced delivery of stem cells and novel strategies for fast examination of myocaridal energetics in vivo using 31P magnetic resonance spectroscopy.
2011-03
Loading...
View/Download File
Persistent link to this item
Statistics
View StatisticsJournal Title
Journal ISSN
Volume Title
Title
Cardiac repair using fibrin patch-based enhanced delivery of stem cells and novel strategies for fast examination of myocaridal energetics in vivo using 31P magnetic resonance spectroscopy.
Authors
Published Date
2011-03
Publisher
Type
Thesis or Dissertation
Abstract
The dissertation is related to heart disease in both basic scientific and pre-clinic respects.
Cardiovascular disease is a leading cause of death in the developed countries even with optimal medical treatment. Recently, the emerging stem cell biology has shown great potentials for cardiac repair. Using both large (swine) and small (rodent) animal models with ischemic heart disease, we examined the functional improvement of enhanced delivery of combined human embryonic stem cell-derived endothelial cells and smooth muscle cells via a fibrin 3D porous scaffold biomatrix. The integration of stem cell biology and tissue engineering has resulted in significant improvement of both regional and global left ventricle function as compared to untreated animals, demonstrating a promising therapeutic strategy of using this cell type and the novel mode of delivery.
As a most energy demanding organ, the heart energetic status is tightly associated with the organ's physiological and pathological conditions. Based on the ultra-high-field magnetic resonance imaging/spectroscopy techniques, we developed a noninvasive modality for rapid examination of cardiac energetics in vivo. The new platform will offer unprecedented understanding into the relationship between the cardiac energetic status and the organ's physiological/pathological conditions, and thus it is of great potential in both basic scientific research and clinical diagnosis.
Description
University of Minnesota Ph.D. dissertation. March 2011. Major: Biomedical Engineering. Advisor: Zhang, Jianyi. 1 computer file (PDF); x, 152 pages.
Related to
Replaces
License
Collections
Series/Report Number
Funding information
Isbn identifier
Doi identifier
Previously Published Citation
Suggested citation
Xiong, Qiang. (2011). Cardiac repair using fibrin patch-based enhanced delivery of stem cells and novel strategies for fast examination of myocaridal energetics in vivo using 31P magnetic resonance spectroscopy.. Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/104631.
Content distributed via the University Digital Conservancy may be subject to additional license and use restrictions applied by the depositor. By using these files, users agree to the Terms of Use. Materials in the UDC may contain content that is disturbing and/or harmful. For more information, please see our statement on harmful content in digital repositories.