Novel Risk Factors and Prevention for Stroke
2022-07
Loading...
View/Download File
Persistent link to this item
Statistics
View StatisticsJournal Title
Journal ISSN
Volume Title
Title
Novel Risk Factors and Prevention for Stroke
Authors
Published Date
2022-07
Publisher
Type
Thesis or Dissertation
Abstract
Stroke is a major public health problem and is a leading cause of long-term disability. Identifying novel risk factors could potentially aid in understanding the mechanisms and pathophysiology of stroke. In addition, atrial fibrillation (AF) is a strong risk factor for stroke and there is a need to understand the risks associated with stroke prevention therapies. Using data from the Atherosclerosis Risk in Communities (ARIC) study, the first manuscript analyzed the cross-sectional association of atrial myopathy—characterized by abnormalities in left atrial (LA) function and size—and brain MRI markers of silent cerebrovascular disease. Several measures of lower LA function were associated with cerebral microbleeds and brain infarcts. In the second manuscript, we explored the relationship of 4,877 plasma proteins to risk of incident ischemic stroke in the ARIC study. Among the proteins that were identified in ARIC, three proteins were validated in an external cohort, the Cardiovascular Health Study. Mendelian randomization analysis suggested that NT-proBNP may be causally related to ischemic stroke. The third manuscript used data from the Medicare 20% sample to assess stroke prevention among patients with AF. The Watchman implant is a minimally invasive procedure for patients with AF who are at an elevated risk for stroke and have an oral anticoagulant contraindication. Compared to oral anticoagulant users, patients with the Watchman device did not have an increased risk of stroke or death. However, an increased risk for bleeding was noted, though this risk was more pronounced in the initial 180 days after the procedure. Collectively, this dissertation identifies novel risk factors for stroke that could contribute to future stroke prevention efforts and also assesses risks associated with current prevention therapies.
Keywords
Description
University of Minnesota Ph.D. dissertation. 2022. Major: Epidemiology. Advisors: Lin Chen, Pamela Lutsey. 1 computer file (PDF); 148 pages.
Related to
Replaces
License
Collections
Series/Report Number
Funding information
Isbn identifier
Doi identifier
Previously Published Citation
Suggested citation
Wang, Wendy. (2022). Novel Risk Factors and Prevention for Stroke. Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/241702.
Content distributed via the University Digital Conservancy may be subject to additional license and use restrictions applied by the depositor. By using these files, users agree to the Terms of Use. Materials in the UDC may contain content that is disturbing and/or harmful. For more information, please see our statement on harmful content in digital repositories.