Polymeric Excipients for the Enhanced Oral Delivery of Poorly Soluble Pharmaceutical Compounds
2019-03
Loading...
View/Download File
Persistent link to this item
Statistics
View StatisticsJournal Title
Journal ISSN
Volume Title
Title
Polymeric Excipients for the Enhanced Oral Delivery of Poorly Soluble Pharmaceutical Compounds
Authors
Published Date
2019-03
Publisher
Type
Thesis or Dissertation
Abstract
The majority of the next generation of pharmaceutical actives that have been discovered to treat diseases, infections, and illnesses are poorly soluble in water, making their inherent bioavailability low and their effective delivery challenging. Poor solubility of a drug can be overcome by formulating the pharmaceutical active into solid dispersions with a polymeric excipient, improving the overall bioavailability of the drug. Excipient choice is paramount to the ultimate behavior of the polymer-drug solid dispersion, and the relationship between excipient properties and solid dispersion behavior is poorly understood. This dissertation describes a systematic evaluation of polymeric materials for the solubility enhancement of phenytoin, a poorly soluble antiepileptic. Through the synthesis and/or modification of polymers for use as excipients, several fundamental relationships between excipient structure and dispersion performance relationships were explored.
Keywords
Description
University of Minnesota Ph.D. dissertation. 2019. Major: Chemistry. Advisor: Marc Hillmyer. 1 computer file (PDF); 207 pages.
Related to
Replaces
License
Collections
Series/Report Number
Funding information
Isbn identifier
Doi identifier
Previously Published Citation
Suggested citation
Johnson, Lindsay. (2019). Polymeric Excipients for the Enhanced Oral Delivery of Poorly Soluble Pharmaceutical Compounds. Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/202904.
Content distributed via the University Digital Conservancy may be subject to additional license and use restrictions applied by the depositor. By using these files, users agree to the Terms of Use. Materials in the UDC may contain content that is disturbing and/or harmful. For more information, please see our statement on harmful content in digital repositories.