The Regulation And Function Of Bmps In Osteoclastogenesis
2019-06
Loading...
View/Download File
Persistent link to this item
Statistics
View StatisticsJournal Title
Journal ISSN
Volume Title
Title
The Regulation And Function Of Bmps In Osteoclastogenesis
Authors
Published Date
2019-06
Publisher
Type
Thesis or Dissertation
Abstract
Bone morphogenetic proteins (BMPs) play a large role in the formation and maintenance of the skeleton, and, in recent years, have become a common clinical adjuvant. The regulatory processes tightly control BMP gradients, which can stimulate both osteoblasts to build bone, and osteoclasts to resorb bone. This thesis discusses data from multiple in-vitro and in-vivo BMP-related knockout models to elucidate the different function BMPs have on osteoclast differentiation and activity. We elucidate the mechanism by which BMP signaling is tightly controlled by Twisted Gastrulation, an extracellular BMP binding protein. Using an murine model we also show osteoclast derived BMP2 acts to regulate bone mineral density in-vivo, and can function to coordinate osteoblast matrix deposition.
Description
University of Minnesota Ph.D. dissertation. June 2019. Major: Dentistry. Advisor: Rajaram Gopalakrishnan. 1 computer file (PDF); vi, 92 pages.
Related to
Replaces
License
Collections
Series/Report Number
Funding information
Isbn identifier
Doi identifier
Previously Published Citation
Suggested citation
Huntley, Raphael. (2019). The Regulation And Function Of Bmps In Osteoclastogenesis. Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/215187.
Content distributed via the University Digital Conservancy may be subject to additional license and use restrictions applied by the depositor. By using these files, users agree to the Terms of Use. Materials in the UDC may contain content that is disturbing and/or harmful. For more information, please see our statement on harmful content in digital repositories.