Liposomes for targeted drug delivery

2013-04-20
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Liposomes for targeted drug delivery

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2013-04-20

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MUC-1 aptamer-amphiphiles were used to functionalize DPPC liposomes to create nanoparticles. Various properties of the targeted liposomes drug delivery vehicles were examined including their drug-to-lipid ratio (DL), targeted ligand insertion efficiency (IE), and stability. The ratio of lipid and MUC-1 aptamer-amphiphile in the liposomes was varied to determine this ratio’s influence on liposomal drug-to lipid ratio, insertion efficiency, and stability. We found that the insertion efficiency and drug-to-lipid ratio is unaffected by the presence of targeting ligand, with a maximum insertion efficiency of 85.4% for the targeted liposomes. The amount of drug loaded into targeted and non-targeted liposomes ranged from 0.10 mg per 1 mg lipids to 0.22 mg per 1 mg lipid. The liposomal leakage was found to be small over the course of 4 days for both targeted and non-targeted liposomal formulations, but there was a 50% increase in leakage in the presence of targeting ligand. The liposomal leakage was lower than 10% for 37°C and 5% in 4°C.

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This research was supported by the Undergraduate Research Opportunities Program (UROP).

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Fei, Wenjie. (2013). Liposomes for targeted drug delivery. Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/150141.

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