Development of light- activatable farnesyltransferase inhibitor

Thumbnail Image

Persistent link to this item

View Statistics

Journal Title

Journal ISSN

Volume Title


Development of light- activatable farnesyltransferase inhibitor

Published Date



Kadiro Nurie




One of the main efforts in the area of drug delivery is to release controlled amount of drug in specific location inside the body where the drug is supposed to affect certain target receptors or cells. The goal of this research project was to synthesize a photo-caged transferase inhibitor (FTI), which is a potential cancer drug. To accomplish this project, nitrodibenzofuran was synthesized as a PPG in order to mask the FTI via attachment to the thiol functionally of the drug. Before working with actual inhibitor, NBDF was synthesized and used for caging cysteamine as a model thiol containing molecule. The goal is to study the photolysis of NDBF-cysteamine via UV and IR irradiation.


Thiol containing compounds play vital roles in various aspects of biology ( enzymatic activity, controlling cellular redox state), protein and peptide chemisty ( e.g. protein and peptide folding, native chemical ligation).

Related to



Series/Report Number

Funding information

This research was supported by the Undergraduate Research Opportunities Program (UROP).

Isbn identifier

Doi identifier

Previously Published Citation

Suggested citation

Nurie, Kadiro. (2015). Development of light- activatable farnesyltransferase inhibitor. Retrieved from the University Digital Conservancy,

Content distributed via the University Digital Conservancy may be subject to additional license and use restrictions applied by the depositor. By using these files, users agree to the Terms of Use. Materials in the UDC may contain content that is disturbing and/or harmful. For more information, please see our statement on harmful content in digital repositories.