The role of bisphosphonates: potential novel pharmaceutical therapy for reducing cardiovascular morbidity and mortality

Loading...

View/Download File

CHEN_umn_0130E_13616.pdf (2.54 MB)

Persistent link to this item

https://hdl.handle.net/11299/150642

Statistics

View Statistics

Journal Title

Journal ISSN

Volume Title

Title

The role of bisphosphonates: potential novel pharmaceutical therapy for reducing cardiovascular morbidity and mortality

Authors

Chen, Yen-Wen

Published Date

2013-04

Publisher

Type

Thesis or Dissertation

Abstract

Cardiovascular disease (CVD) is one of the most significant and costly public health problems in the U.S. and worldwide. In addition to the well-established risk factors, such as hypertension or diabetes, growing bodies of studies have demonstrated that vascular calcification is another strong and independent predictor of cardiovascular morbidity and mortality. The pathological process of vascular calcification includes many key modulators of bone and mineral metabolism. Hence, the question is raised regarding whether pharmacological agents for inhibiting bone loss can also provide a beneficial impact on inhibiting vascular calcification to lower CVD risks. The primary objectives of this study were to: 1) examine the association between bisphosphonate use and the risk of a composite endpoint of congestive heart failure (CHF), myocardial infarction (MI) or stroke hospitalization, and 2) examine the impact of patient adherence to bisphosphonate therapy on the risk of CHF, MI or stroke hospitalization.

Keywords

bisphosphonate

cardiovascular disease

osteoporosis

vascular calcification

Description

University of Minnesota PH.D. dissertation. April 2013. Major: Social, Administrative, and Clinical Pharmacy. Advisor: Dr. Wendy St. Peter. 1 computer file (PDF); xi, 126 pages, appendices 1-6.

Related to

Replaces

License

Collections

Dissertations

Series/Report Number

Funding information

Isbn identifier

Doi identifier

Previously Published Citation

Suggested citation

Chen, Yen-Wen. (2013). The role of bisphosphonates: potential novel pharmaceutical therapy for reducing cardiovascular morbidity and mortality. Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/150642.

Content distributed via the University Digital Conservancy may be subject to additional license and use restrictions applied by the depositor. By using these files, users agree to the Terms of Use. Materials in the UDC may contain content that is disturbing and/or harmful. For more information, please see our statement on harmful content in digital repositories.