Discovery, characterization, and pharmaceutical applications of two loratadine- oxalic acid cocrystals
2020-08
Loading...
View/Download File
Persistent link to this item
Statistics
View StatisticsJournal Title
Journal ISSN
Volume Title
Title
Discovery, characterization, and pharmaceutical applications of two loratadine- oxalic acid cocrystals
Authors
Published Date
2020-08
Publisher
Type
Thesis or Dissertation
Abstract
Crystallization of multi-component crystals is widely used in pharmaceutical science to enhance the physiochemical properties, such as stability, mechanical properties and solubility. Loratadine (Lor) is a BCS II antihistamine drug commonly used to relieve the symptoms of allergy. It has high permeability but low solubility at physiological pHs. To overcome the problem of low solubility, we synthesized and fully characterized two Loratadine multi-component crystalline phases with oxalic acid (Oxa), i.e., a 1:1 Lor-Oxa conjugate acid-base cocrystal (Lor-Oxa CAB) and a 2:1 Lor-Oxa cocrystal monohydrate (Lor-Oxa hydrate). Both cocrystals exhibited adequate physical stability, enhanced solubility and, higher intrinsic dissolution rate than Lor. The intrinsic dissolution rate of Lor-Oxa CAB is 90 times that of Lor, which makes it a promising candidate for tablet formulation development.
Description
University of Minnesota M.S. thesis. 2020. Major: Pharmaceutics. Advisor: Changquan Sun. 1 computer file (PDF); 64 pages.
Related to
Replaces
License
Series/Report Number
Funding information
Isbn identifier
Doi identifier
Previously Published Citation
Suggested citation
Liang, Zhengxuan. (2020). Discovery, characterization, and pharmaceutical applications of two loratadine- oxalic acid cocrystals. Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/224887.
Content distributed via the University Digital Conservancy may be subject to additional license and use restrictions applied by the depositor. By using these files, users agree to the Terms of Use. Materials in the UDC may contain content that is disturbing and/or harmful. For more information, please see our statement on harmful content in digital repositories.