A translational approach to the neurobiology of persecutory ideation in schizophrenia.

Loading...
Thumbnail Image

Persistent link to this item

Statistics
View Statistics

Journal Title

Journal ISSN

Volume Title

Title

A translational approach to the neurobiology of persecutory ideation in schizophrenia.

Published Date

2011-08

Publisher

Type

Thesis or Dissertation

Abstract

The heterogeneous symptom presentation of schizophrenia has created difficulties in understanding the disease's biological basis. As a result, researchers have adopted dimension or symptom-specific methodologies to identify the disease's etiology. Another successful research method in schizophrenia involves the translation of experimental paradigms designed to study the neurobiology of cognitive mechanisms through multiple levels of inquiry. The current manuscript described the translation of an economic decision-making paradigm into a sample of individuals with schizophrenia. Results showed that patients with schizophrenia in this sample were able to understand the paradigm and as predicted showed behavioral results similar to controls. A symptom measure of persecutory ideation showed a specific relationship to a decision-making bias that has been reliably associated with persecutory ideation in control samples. In terms of neuroimaging results, patients activated the paracingulate cortex, anterior cingulate cortex, orbital frontal cortex, insula and amygdala when deciding whether or not to trust another player. These same regions were not activated when deciding whether or not to let a coin-flip determine their winnings. Of the regions activated when deciding to trust another player, only the anterior cingulate cortex correlated with a measure of persecutory ideation. Results suggest that economic decision-making paradigms can produce fruitful results in psychiatric samples. Additionally, the findings suggest a specific relationship between the self-referential thinking associated with persecutory ideation and the anterior cingulate cortex.

Description

University of Minnesota Ph.D. dissertation. August 2011. Major: Psychology. Advisor: Angus W. MacDonald III, Ph.D. 1 computer file (PDF); ix, 126 pages, appendices 1-4.

Related to

Replaces

License

Collections

Series/Report Number

Funding information

Isbn identifier

Doi identifier

Previously Published Citation

Other identifiers

Suggested citation

Johnson, Melissa Kay. (2011). A translational approach to the neurobiology of persecutory ideation in schizophrenia.. Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/116198.

Content distributed via the University Digital Conservancy may be subject to additional license and use restrictions applied by the depositor. By using these files, users agree to the Terms of Use. Materials in the UDC may contain content that is disturbing and/or harmful. For more information, please see our statement on harmful content in digital repositories.