The Role of Anergy in Peripheral Regulatory T cell Generation

Kalekar, Lokesh
2016-06
Thumbnail Image

View/Download File

Kalekar_umn_0130E_17229.pdf (9.54 MB)

Persistent link to this item

https://hdl.handle.net/11299/182291
Statistics
View Statistics

Journal Title

Journal ISSN

Volume Title

Title

The Role of Anergy in Peripheral Regulatory T cell Generation

Authors

Published Date

2016-06

Publisher

Type

Thesis or Dissertation

Abstract

The role that anergy, an acquired state of T cell functional unresponsiveness, plays in natural peripheral tolerance remains unclear. In this study, we demonstrate that anergy is selectively induced in fetal antigen-specific maternal CD4+ T cells during pregnancy. A naturally occurring subpopulation of anergic polyclonal CD4+ T cells, enriched in self antigen-specific T cell receptors, is also observed in healthy hosts. Neuropilin-1 expression in anergic conventional CD4+ T cells is associated with thymic regulatory T cell (Treg cell)-related gene hypomethylation, and this correlates with their capacity to differentiate into Foxp3+ Treg cells that suppress immunopathology. Thus, our data suggest that not only is anergy induction important in preventing autoimmunity, but it also generates the precursors for peripheral Treg cell differentiation

Keywords

Description

University of Minnesota Ph.D. dissertation. June 2016. Major: Microbiology, Immunology and Cancer Biology. Advisor: Daniel Mueller. 1 computer file (PDF); vii, 122 pages.

Related to

Replaces

License

Collections

Dissertations

Series/Report Number

Funding information

Isbn identifier

Doi identifier

Previously Published Citation

Suggested citation

Kalekar, Lokesh. (2016). The Role of Anergy in Peripheral Regulatory T cell Generation. Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/182291.

Content distributed via the University Digital Conservancy may be subject to additional license and use restrictions applied by the depositor. By using these files, users agree to the Terms of Use. Materials in the UDC may contain content that is disturbing and/or harmful. For more information, please see our statement on harmful content in digital repositories.