Characterization of blood flow in the retinal vascular network
2015-01
Loading...
View/Download File
Persistent link to this item
Statistics
View StatisticsJournal Title
Journal ISSN
Volume Title
Title
Characterization of blood flow in the retinal vascular network
Authors
Published Date
2015-01
Publisher
Type
Thesis or Dissertation
Abstract
The primary goal of the work presented here is to understand how blood flow is regulated in the retinal vascular network in response to neuronal activity. In order to accurately quantify blood flow, we developed a multitude of streamlined techniques capable of measuring many properties of blood flow. These techniques were used to investigate retinal functional hyperemia, defined as the increase in local blood flow that occurs in response to nearby neuronal activity. We did a comprehensive survey of all retinal vessels to investigate the magnitude and timing of the functional hyperemia response as it presents in the different compartments of the retinal vascular network. We found that arterioles are primarily responsible for generating functional hyperemia in the retina and that, with prolonged stimulation, blood flow through the three vascular layers in the retina is differentially regulated. This result implies the presence of active capillary dilation. The work in this dissertation informs our understanding of blood flow regulation within the retinal vascular network.
Description
University of Minnesota Ph.D. dissertation. January 2015. Major: Neuroscience. Advisor: Eric A. Newman. 1 computer file (PDF); vi, 84 pages.
Related to
Replaces
License
Collections
Series/Report Number
Funding information
Isbn identifier
Doi identifier
Previously Published Citation
Suggested citation
Kornfield, Tess Ellen. (2015). Characterization of blood flow in the retinal vascular network. Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/171413.
Content distributed via the University Digital Conservancy may be subject to additional license and use restrictions applied by the depositor. By using these files, users agree to the Terms of Use. Materials in the UDC may contain content that is disturbing and/or harmful. For more information, please see our statement on harmful content in digital repositories.