Biological Function of Nectin 4 in Ovarian Cancer
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Ovarian Cancer Overview: 5th leading cause of cancer death for women in the U.S.; Most patients diagnosed after metastasis, when survival rates are low; Early diagnosis yields 93% five year survival rate.
Biomarkers and Nectin 4: Biomarkers have different properties: early detection, clues to therapy effectiveness, and possible prognostic applications; Nectin 4 has been identified by the Skubitz lab as a possible biomarker. Nectins belong to a family of immunoglobulin-like proteins important in cell to cell adhesion; A study of 500 ovarian cancer tumors showed 48.6% stained for Nectin 4 in the tumor while 53% of ovarian cancer blood samples tested positive. Nectin 4 also expressed in lung cancer.
Our hypothesis is that knocking down the expression of Nectin 4 will inhibit ovarian cancer cell function and metastasis.
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This research was supported by the Undergraduate Research Opportunities Program (UROP).
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Meyer, Adam. (2012). Biological Function of Nectin 4 in Ovarian Cancer. Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/140921.
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