Creation of a DNA Substrate for the Investigation of DNA-Protein Crosslinks

Anwah, Ifeanyirochukwu G.
2010-04-21
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Creation of a DNA Substrate for the Investigation of DNA-Protein Crosslinks

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2010-04-21

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Bialkylating agents form DNA-protein crosslinks (DPCs) as a side reaction. Bialkylating agents belong to a class of drugs used to treat cancer that function by forming DNA-DNA crosslinks and interfering with DNA function. To a lesser extent, they also form DNA-protein crosslinks (DPCs). DPCs are know to be harmful to the cell, but they have not been well-studied. The aim of our research was to study these DPCs and better understand their mechanism of action. A better understanding of the function of DPCs could one day contribute to the development of novel and more efficacious drugs used to treat cancer.

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Additional contributors: Thuy Nguyen-Tran; Colin R. Campbell (faculty mentor)

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UMTC Undergraduate Research Presentations and Papers (UROP)

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Anwah, Ifeanyirochukwu G.. (2010). Creation of a DNA Substrate for the Investigation of DNA-Protein Crosslinks. Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/90864.

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