Between Dec 19, 2024 and Jan 2, 2025, datasets can be submitted to DRUM but will not be processed until after the break. Staff will not be available to answer email during this period, and will not be able to provide DOIs until after Jan 2. If you are in need of a DOI during this period, consider Dryad or OpenICPSR. Submission responses to the UDC may also be delayed during this time.
 

A Combination Antioxidant Therapy in the Treatment and Prevention of Age Related Hearing Loss

Loading...
Thumbnail Image

Persistent link to this item

Statistics
View Statistics

Journal Title

Journal ISSN

Volume Title

Title

A Combination Antioxidant Therapy in the Treatment and Prevention of Age Related Hearing Loss

Published Date

2015-07

Publisher

Type

Thesis or Dissertation

Abstract

Presbycusis, or age-related hearing loss, is one of the most common conditions impacting the aging population, characterized by progressive sensorineural hearing loss and impairment in speech discrimination capability. Current management is limited to auditory rehabilitation with the assistance of hearing aids or cochlear implants in advanced cases. There currently exists no effective treatments available for the prevention or attenuation of hearing loss in association with presbycusis. The purpose of this study was to evaluate the potential of a combination antioxidant therapy in the prevention and treatment of presbycusis. The objectives of this randomized controlled animal study were to: identify an anesthetic which would allow for repeated reliable longitudinal auditory brainstem response (ABR) testing in a mouse model, identify a combination antioxidant which targets multiple sites within the oxidative pathway and assess its ability to prevent age-related threshold shifts and to arrest further age-related threshold shifts in C57BL6 mice with documented age-related threshold shifts. Mice were randomized to one of three groups: an early treatment group, a late treatment group, or a control group. The treatment groups of mice were fed with a combination agent comprised 6 antioxidant agents. ABRs were performed comparing Avertin to ketamine/xylazine with no significant difference in test thresholds. ABR thresholds were recorded at baseline and every 3 months following initiation of treatment in the 3 randomized groups. Threshold shifts from baseline were decreased in the treatment groups when compared to the control group at all tested frequencies and time points.Presbycusis, or age-related hearing loss, is one of the most common conditions impacting the aging population, characterized by progressive sensorineural hearing loss and impairment in speech discrimination capability. Current management is limited to auditory rehabilitation with the assistance of hearing aids or cochlear implants in advanced cases. There currently exists no effective treatments available for the prevention or attenuation of hearing loss in association with presbycusis. The purpose of this study was to evaluate the potential of a combination antioxidant therapy in the prevention and treatment of presbycusis. The objectives of this randomized controlled animal study were to: identify an anesthetic which would allow for repeated reliable longitudinal auditory brainstem response (ABR) testing in a mouse model, identify a combination antioxidant which targets multiple sites within the oxidative pathway and assess its ability to prevent age-related threshold shifts and to arrest further age-related threshold shifts in C57BL6 mice with documented age-related threshold shifts. Mice were randomized to one of three groups: an early treatment group, a late treatment group, or a control group. The treatment groups of mice were fed with a combination agent comprised 6 antioxidant agents. ABRs were performed comparing Avertin to ketamine/xylazine with no significant difference in test thresholds. ABR thresholds were recorded at baseline and every 3 months following initiation of treatment in the 3 randomized groups. Threshold shifts from baseline were decreased in the treatment groups when compared to the control group at all tested frequencies and time points.

Description

University of Minnesota Ph.D. dissertation. July 2015. Major: Otolaryngology. Advisors: Rick Odland, Steven Juhn. 1 computer file (PDF); vi, 159 pages.

Related to

Replaces

License

Collections

Series/Report Number

Funding information

Isbn identifier

Doi identifier

Previously Published Citation

Other identifiers

Suggested citation

Heman-Ackah, Selena. (2015). A Combination Antioxidant Therapy in the Treatment and Prevention of Age Related Hearing Loss. Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/175462.

Content distributed via the University Digital Conservancy may be subject to additional license and use restrictions applied by the depositor. By using these files, users agree to the Terms of Use. Materials in the UDC may contain content that is disturbing and/or harmful. For more information, please see our statement on harmful content in digital repositories.