Supporting transition cow health: tailoring hyperketonemia treatment and periparturient supplementation

Abstract

The transition period in dairy cows is characterized by complex metabolic and inflammatory adaptations. Inadequate adaptation during this period increases the risk of disease and impairs productive performance. This thesis evaluated two independent strategies aimed at improving transition cow health. In Chapter 2, a randomized controlled trial assessed the effects of pre- and post-partum oral mineral supplementation on milk yield and blood metabolite profiles in 1,275 cows. Although minor improvements in metabolic indicators were observed, no benefit to milk production was detected, suggesting limited utility in well-managed herds. Chapter 3 investigated whether baseline metabolic status affected the likelihood of hyperketonemia resolution following propylene glycol treatment in diagnosed cows. Even though cows with lower non-esterified fatty acid concentrations were less likely to remain hyperketonemic, no significant interactions were observed between treatment response and baseline metabolic indicators. These studies contribute to the understanding of transition cow management by identifying opportunities for more efficient and tailored intervention strategies.