Identifying Possible Causative Mutations of Dwarfism in Great Pyrenees

Loading...
Thumbnail Image

View/Download File

Persistent link to this item

Statistics
View Statistics

Journal Title

Journal ISSN

Volume Title

Title

Identifying Possible Causative Mutations of Dwarfism in Great Pyrenees

Alternative title

Published Date

2018

Publisher

Type

Presentation

Abstract

Dwarfism in Great Pyrenees is characterized by short, abnormal bones, and has anecdotal associations with deafness. Previous studies have argued for an autosomal recessive mode of inheritance. In the search for candidate mutations associated with dwarfism in Great Pyrenees, we collected DNA from 12 dwarf and 17 unaffected Great Pyrenees. A genome-wide association study of the 29 dogs showed a statistically significant correlation between the dwarf phenotype and SNPs on chromosome 33. We narrowed SNPs of interest on chromosome 33 down to a 2.5Mbp region.

Keywords

Description

Faculty Advisor: James Mickelson

Related to

Replaces

License

Series/Report Number

Funding information

This research was supported by the Undergraduate Research Opportunities Program (UROP).

Isbn identifier

Doi identifier

Previously Published Citation

Other identifiers

Suggested citation

Minor, Katie; Donahue, Nolan; Mickelson, James. (2018). Identifying Possible Causative Mutations of Dwarfism in Great Pyrenees. Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/201201.

Content distributed via the University Digital Conservancy may be subject to additional license and use restrictions applied by the depositor. By using these files, users agree to the Terms of Use. Materials in the UDC may contain content that is disturbing and/or harmful. For more information, please see our statement on harmful content in digital repositories.