Identifying Possible Causative Mutations of Dwarfism in Great Pyrenees

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Identifying Possible Causative Mutations of Dwarfism in Great Pyrenees

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Dwarfism in Great Pyrenees is characterized by short, abnormal bones, and has anecdotal associations with deafness. Previous studies have argued for an autosomal recessive mode of inheritance. In the search for candidate mutations associated with dwarfism in Great Pyrenees, we collected DNA from 12 dwarf and 17 unaffected Great Pyrenees. A genome-wide association study of the 29 dogs showed a statistically significant correlation between the dwarf phenotype and SNPs on chromosome 33. We narrowed SNPs of interest on chromosome 33 down to a 2.5Mbp region.



Faculty Advisor: James Mickelson

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This research was supported by the Undergraduate Research Opportunities Program (UROP).

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Minor, Katie; Donahue, Nolan; Mickelson, James. (2018). Identifying Possible Causative Mutations of Dwarfism in Great Pyrenees. Retrieved from the University Digital Conservancy,

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