Synthesis and evaluation of acridine and acridone based compound as anti-Cancer and anti-bacterial agents

Loading...
Thumbnail Image

Persistent link to this item

Statistics
View Statistics

Journal Title

Journal ISSN

Volume Title

Title

Synthesis and evaluation of acridine and acridone based compound as anti-Cancer and anti-bacterial agents

Published Date

2013-12

Publisher

Type

Thesis or Dissertation

Abstract

After the discovery of acridine in the late 1800's, the acridine class of molecules attracted much synthetic interest due to their usefulness as dyestuffs and the discovery that certain acridine derivatives possessed anti-bacterial properties. It was this discovery that lead aminoacridines to be used heavily as anti-bacterial agents until they were supplanted by the use of sulfonamides and the discovery of the penicillin's. Despite falling out of favor as anti-bacterial agents, acridine derivatives were still used in the treatment of other diseases such as malaria and cancer.Despite falling out of use as anti-bacterial agents, one area where the acridine class of compounds may find a new use is in the treatment of drug-resistant bacterial infections, namely MRSA. Infections caused by numerous drug-resistant bacteria have become a major health issue in the world today which has led to a pressing need for the development of novel agents to treat these infections.We report within this thesis the synthesis and evaluation of numerous acridine and acridone based compounds that possess activity against a number of strains of MRSA. In an attempt to elucidate a potential mechanism of action, the active compounds were also tested in DNA intercalation assays and screens against other known bacterial targets. Despite our best efforts, the mechanism of these novel acridine compounds was not elucidated and is hypothesized to be an interaction with the bacterial cell membrane.

Keywords

Description

University of Minnesota Ph.D. dissertation. December 2013. Major: Medicinal Chemistry. Advisor: David M. Ferguson. 1 computer file (PDF); v, 109 pages.

Related to

Replaces

License

Collections

Series/Report Number

Funding information

Isbn identifier

Doi identifier

Previously Published Citation

Suggested citation

Benoit, Adam Richard. (2013). Synthesis and evaluation of acridine and acridone based compound as anti-Cancer and anti-bacterial agents. Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/162419.

Content distributed via the University Digital Conservancy may be subject to additional license and use restrictions applied by the depositor. By using these files, users agree to the Terms of Use. Materials in the UDC may contain content that is disturbing and/or harmful. For more information, please see our statement on harmful content in digital repositories.