Ion Channel Activity of Muscle Regulatory Proteins Sarcolipin and Phospholamban

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Ion Channel Activity of Muscle Regulatory Proteins Sarcolipin and Phospholamban

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2012-04-18

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Abstract

The proposed research will investigate the role of two key proteins, sarcolipin (SLN) and phospholamban (PLB), in muscle contractility. Both SLN and PLB monomers have a primary regulatory function of inhibiting calcium (Ca) transport of the sarcoplasmic reticulum Ca-ATPase (SERCA). SLN inhibits SERCA in skeletal muscle, while PLB inhibits SERCA in cardiac muscle. Adrenaline phosphorylates SLN and PLB, reversing SERCA inhibition and stimulating muscle contraction. This research project will examine a potential second function of SLN and PLB: the formation of ion transport channels.

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Faculty Advisor: David D Thomas

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This research was supported by the Undergraduate Research Opportunities Program (UROP).

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DesLauriers, Nicholas. (2012). Ion Channel Activity of Muscle Regulatory Proteins Sarcolipin and Phospholamban. Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/130393.

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