The Genetics of General Cognitive Ability

Loading...
Thumbnail Image

Persistent link to this item

Statistics
View Statistics

Journal Title

Journal ISSN

Volume Title

Title

The Genetics of General Cognitive Ability

Published Date

2013-05

Publisher

Type

Thesis or Dissertation

Abstract

General cognitive ability (GCA) is a highly heritable trait, with correlates in numerous other domains. This dissertation reports the results of three studies of the genetics of GCA, conducted with participants from the Minnesota Center for Twin & Family Research (MCTFR). Study #1 (N = 7,100) is a genome-wide association study plus other analyses that exploit genome-wide single-nucleotide polymorphism (SNP) data. Study #2 (N = 6,439) is an association study of a different class of genetic polymorphism, the copy-number variant (CNV). In this study, we detect CNVs from genome-wide SNP-allele-probe intensity data. We aggregate them into genome-wide mutational burden scores and also carry out genome-wide association scans for specific CNVs. Study #3 is a biometric moderation study in a sample of 2,494 pairs of twins, full siblings, and adoptive siblings. We compared models by their sample-size-corrected AIC, and based our parametric inference on model-averaged point estimates and standard errors. Taken as a whole, these three studies demonstrate that GCA is substantially heritable and massively polygenic, but it is also influenced by environmental factors, and its heritability can be moderated by contextual variables like age and family-of-origin socioeconomic status (SES).

Description

University of Minnesota Ph.D. dissertation. May 2013. Major: Psychology. Advisors: Matthew McGue, Niels Waller. 1 computer file (PDF); v, 140 pages.

Related to

Replaces

License

Collections

Series/Report Number

Funding information

Isbn identifier

Doi identifier

Previously Published Citation

Suggested citation

Kirkpatrick, Robert. (2013). The Genetics of General Cognitive Ability. Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/173929.

Content distributed via the University Digital Conservancy may be subject to additional license and use restrictions applied by the depositor. By using these files, users agree to the Terms of Use. Materials in the UDC may contain content that is disturbing and/or harmful. For more information, please see our statement on harmful content in digital repositories.