Synthesis of Sulfur-Containing Heterocycles as Potential Biologically Active Molecules

Abstract

Previous research in Dr. Noland’s group is focused on heterocyclic nitrogen and sulfur compounds, with the emphasis on synthesis, mechanisms, and submission of compounds for medicinal activity testing. To date, several derivatives synthesized in the laboratory have shown activity against cancer cells or the HIV-1 virus. In my project, I attempted the Diels-Alder reaction with 2-(1-phenylethenyl)- thiophene and several dienophiles to form novel products with intended submission to the National Institute of Health for biological activity testing. The structures of the products are determined by modern spectroscopic techniques, including infrared, nuclear magnetic resonance, mass spectral, and ultraviolet methods. All expected products are either discovered in low yields or not discovered, suggesting an analysis of the proposed mechanism and further trials with additional dienophiles.