Chromatin/Nuclear Architecture Roles in Chromosome Structure and Function (2021-01-15)
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Chromatin/Nuclear Architecture Roles in Chromosome Structure and Function (2021-01-15)
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2021
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Abstract
Although early paradigms for regulation of gene expression focused almost exclusively on transcription factor binding and recruitment of the RNA polymerase, we now know that gene expression levels can be exquisitely calibrated by chromatin structure and nuclear architectural influences. And although histone modifications were first described as a "code" linked to "active" or "silent" chromatin states, work in my lab and others are revealing how these marks play a much more dynamic role in modulating gene function and chromosome behavior. In this presentation I will propose a model for enzymatic and non-enzymatic mechanisms by which the JIL-1 H3S10 kinase influences chromatin structure and chromosome architectural organization, and discuss developmental and physiological consequences of JIL-1 dysfunction.
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Department of Biology Seminar this Friday, January 15, 2021 at 3:00 pm on Zoom; Kristen Johansen, Roy J Carver Professor and Department Chair at Iowa State University; Hosted by: Dr. Huai Deng; Friday January 15, 2021; We encourage you to join us at https://z.umn.edu/scsefriday at 3:00 PM
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Johansen, Kristen; University of Minnesota Duluth. Department of Biology. (2021). Chromatin/Nuclear Architecture Roles in Chromosome Structure and Function (2021-01-15). Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/220645.
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