Naked-eye visualization of nucleic acid amplicons using hierarchical nanoassembly

Novi, Vinni Thekkudan
Abbas, Abdennour
2023-08

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https://hdl.handle.net/11299/255770
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Naked-eye visualization of nucleic acid amplicons using hierarchical nanoassembly

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2023-08

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Analytical Methods

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Article

Abstract

This study reports the development of a rapid visualization method for DNA amplicons. Oligonucleotide-coated gold nanoparticles hierarchically assemble on DNA networks to form globular nanostructures, which precipitate into a distinct visible red pellet. This aims to overcome challenges associated with nanoparticle aggregation and dye-based colorimetric detection in LAMP assays.

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Minnesota Environment and Natural Resource Trust Fund as recommended by the Legislative Citizen Commission on Minnesota’s Resources through the Minnesota Invasive Terrestrial Plants and Pests Center; USDA National Institute of Food and Agriculture, Hatch project 1006789

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10.1039/D3AY01050C

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V. T. Novi and A. Abbas. Naked-eye visualization of nucleic acid amplicons using hierarchical nanoassembly. Analytical Methods, 2023, DOI: 10.1039/D3AY01050C.

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