Bone Mineral Density and Body Composition in Children with Congenital Adrenal Hyperplasia
2017-12
Loading...
View/Download File
Persistent link to this item
Statistics
View StatisticsJournal Title
Journal ISSN
Volume Title
Title
Bone Mineral Density and Body Composition in Children with Congenital Adrenal Hyperplasia
Authors
Published Date
2017-12
Publisher
Type
Thesis or Dissertation
Abstract
Background: Children with congenital adrenal hyperplasia (CAH) are exposed to fluctuating cortisol and androgen levels. The effects these hormonal states have on bone mineral density (BMD) and body composition are not well studied. Objective: Compare BMD and body composition in children with CAH vs. healthy age-, sex-, and BMI-matched controls. Methods: Forty-two cases with CAH and 101 controls underwent a dual-energy X-ray absorptiometry scan. Bone age Z-scores were used as a surrogate for long-term androgen exposure in cases. Results: Children with CAH had lower BMD Z-scores than controls. In CAH cases, BMD Z-scores were positively correlated with bone age Z-scores. Body composition markers did not differ between children with CAH and controls. Conclusion: Lower BMD was observed in CAH cases, but no differences in body composition were identified. Among CAH cases, increased chronic androgen exposure, as measured by bone age Z-scores, was associated with higher BMD.
Description
University of Minnesota M.S. thesis. December 2017. Major: Clinical Research. Advisor: Antoinette Moran. 1 computer file (PDF); vi, 21 pages.
Related to
Replaces
License
Series/Report Number
Funding information
Isbn identifier
Doi identifier
Previously Published Citation
Suggested citation
Halper, Alyssa. (2017). Bone Mineral Density and Body Composition in Children with Congenital Adrenal Hyperplasia. Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/211729.
Content distributed via the University Digital Conservancy may be subject to additional license and use restrictions applied by the depositor. By using these files, users agree to the Terms of Use. Materials in the UDC may contain content that is disturbing and/or harmful. For more information, please see our statement on harmful content in digital repositories.