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Effect of N1-hexyl-N5-benzyl-biguanide mesylate (HBB) on Immediate Early Hormonal Signaling in MCF-7 Breast Cancer Cells
Ji, Michelle, M (2016)
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https://hdl.handle.net/11299/181614
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Title
Effect of N1-hexyl-N5-benzyl-biguanide mesylate (HBB) on Immediate Early Hormonal Signaling in MCF-7 Breast Cancer Cells
Authors
Issue Date
2016
Type
Presentation
Abstract
HBB is a chemical compound being tested as a possible drug to treat breast cancer in addition to other hormone therapies. However, its mechanism remains unclear. This set of experiments was done to understand how HBB treated cells react upon exposure to either estradiol or progesterone. By using western blot assays, it was determined that phosphorylated ERK levels increased in cells treated with HBB.
Keywords
HBB
Appears in collections
UMTC Undergraduate Research Presentations and Papers (UROP) [1609]
Funding information
This research was supported by the Undergraduate Research Opportunities Program (UROP).
Suggested Citation
Ji, Michelle, M. (2016). Effect of N1-hexyl-N5-benzyl-biguanide mesylate (HBB) on Immediate Early Hormonal Signaling in MCF-7 Breast Cancer Cells. Retrieved from the University of Minnesota Digital Conservancy, https://hdl.handle.net/11299/181614.
Content distributed via the University of Minnesota's Digital Conservancy may be subject to additional license and use restrictions applied by the depositor.