Enhancing the potency and water solubility of the sesquiterpene lactone parthenolide
2013-03
Loading...
View/Download File
Persistent link to this item
Statistics
View StatisticsJournal Title
Journal ISSN
Volume Title
Title
Enhancing the potency and water solubility of the sesquiterpene lactone parthenolide
Authors
Andrews, Timothy Edward
Published Date
2013-03
Publisher
Type
Thesis or Dissertation
Abstract
Most commercially available chemotherapeutics targeting acute myeloid leukemia (AML) lack the ability to target cancer stem cells, one of the central reasons for cancer relapse. The natural product parthenolide is able to ablate the cancer stem cell population within tumors, which is paramount to it currently being developed as a clinical candidate. Unfortunately, parthenolide is not a perfect therapeutic, its modest potency and poor water solubility hinder its development. The focus of this thesis is to optimize parthenolide as a clinical candidate, by addressing the aforementioned concerns with parthenolide. A parthenolide analogue library was synthesized that varied different parts of the natural product in an effort to enhance the potency and water solubility. In addition, conjugation of parthenolide to a gold nanoparticle delivery system was also investigated as another method to attempt to optimize parthenolide. These alterations will be useful in the continuous development of parthenolide as a promising therapeutic against cancer and specifically cancer stem cells.
Keywords
Description
University of Minnesota M.S. thesis. March 2013. Major: Medicinal Chemistry. Advisor: Daniel A. Harki. 1 computer file (PDF); xii, 151 pages, appendix A.
Related to
Replaces
License
Series/Report Number
Funding information
Isbn identifier
Doi identifier
Previously Published Citation
Suggested citation
Andrews, Timothy Edward. (2013). Enhancing the potency and water solubility of the sesquiterpene lactone parthenolide. Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/162298.
Content distributed via the University Digital Conservancy may be subject to additional license and use restrictions applied by the depositor. By using these files, users agree to the Terms of Use. Materials in the UDC may contain content that is disturbing and/or harmful. For more information, please see our statement on harmful content in digital repositories.