Application of the Dieckmann Condensation to Pyrrole Diesters

Choi, Jua
2012-04-18

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Application of the Dieckmann Condensation to Pyrrole Diesters

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2012-04-18

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The Dieckmann condensation is commonly used in preparation of cyclic indole. The heterocyclic indole can be biologically active against cancer. The application of the Dieckmann condensation in the formation of five-membered pyrrole rings has not been previously reported in literature, making the procedure novel. Using extra equivalents of AlCl3 and Et3N allowed for the successful synthesis of cyclized pyrroles. Whether another choice of Lewis acids may also succeed the reaction remains to be discovered.

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Mentor: Wayland E. Noland

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This research was supported by the Undergraduate Research Opportunities Program (UROP).

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