Inhibition of NRAS signaling in an in vitro model of human MLL-AF9/NRAS^G12V acute myeloid leukemia

Hazen, Katherine
Eckfeldt, Craig
Largaespada, David
2011-09-16
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Hazen UROP Summer 2011 poster edit 1.pdf (1.4 MB)

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Inhibition of NRAS signaling in an in vitro model of human MLL-AF9/NRAS^G12V acute myeloid leukemia

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2011-09-16

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Objective and Hypothesis: Investigate the therapeutic potential of NRAS-targeted therapy in the human MLL-AF9 and NRASG12V-driven AML cell line THP-1 using shRNA and small molecule inhibitors. We hypothesize that inhibition of NRAS using shRNA and inhibition of PI3K/AKT/mTOR and RAF/MEK/ERK pathways using small molecule inhibitors will lead to leukemic cell death.

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This project was supported by a University of Minnesota Undergraduate Research Opportunities Program grant.

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Hazen, Katherine; Eckfeldt, Craig; Largaespada, David. (2011). Inhibition of NRAS signaling in an in vitro model of human MLL-AF9/NRAS^G12V acute myeloid leukemia. Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/118420.

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