Browsing by Subject "tacrolimus"

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    Genetic Variants Associated with Tacrolimus Metabolism in Kidney Transplant Recipients
    (2023-08) Dorr, Casey
    This master’s thesis focuses on the work completed during my K01 award Genetic Variants Associated with Tacrolimus (TAC) metabolism in Kidney Transplant Recipients. In Chapter 1, I discuss the significance and innovations of this project. In Chapter 2, I present reformatted manuscript published in the Pharmacogenomics Journal titled: Identification of genetic variants associated with tacrolimus metabolism in kidney transplant recipients by extreme phenotype sampling and next generation sequencing. In Chapter 3, I present a reformatted manuscript published in Drug Metabolism and Disposition titled: CRISPR/Cas9 genetic modification of CYP3A5 *3 in human hepatocytes leads to cell lines with increased midazolam and tacrolimus metabolism. Chapter 4 is the general conclusions, future directions and take away messages.