Browsing by Subject "Pharmaceutical industry"

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    Lubrication In Pharmaceutical Tablet Manufacturing
    (2020-03) Dun, Jiangnan
    Appropriate compaction properties are critical to ensure a successful and robust tablet manufacture. According to Materials Science Tetrahedron (MST) theory, the quality of the tablet product is determined by the properties of pharmaceutical materials and the process conditions during manufacture. Lubricant, as one of the most important tablet excipients, has great impacts on the flow and mechanical properties of formulation. This work is heavily focused on understanding of the effects of process parameters on the lubrication as well as development of new lubricants for tablet formulation. Magnesium stearate, the most commonly used tablet lubricant, though exhibits excellent lubrication efficiency, leads to deterioration in tablet strength and dissolution. Sodium lauryl sulfate (SLS), Poloxamer 188 and Poloxamer 407 were selected as MgSt-alternative lubricants to be tested in tablet formulations. We found that the lubrication efficiency of these three materials are comparable with MgSt. More importantly, no significant tablet strength reduction was observed. Given to the higher hydrophilicity, tablets containing either of SLS, P188 or P407 showed enhanced dissolution profiles compared with MgSt containing tablets. Furthermore, robustness of formulation was remarkably improved when P188 or P407 was used as lubricant.
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    Repeated Alliances Across Product Markets: The Formation and Performance Implications
    (2023) Park, Sohyuun
    This dissertation explores a phenomenon of market entry through cross-market repeated alliance, or market entry through repeated alliance with an existing partner from another product market. While it has been studied much how firms use its internal resources to enter a product market, relational resources have received little attention as valuable firm resources in market entry. Such lack of studies on the use of relational resources in market entry is surprising, considering that strategic alliance is an important strategic tool of firms. In this regard, in the first chapter, I examine when firms enter product markets through cross-market repeated alliances with existing partners rather than find new partners. Furthermore, the second chapter studies the performance implications of such cross-market repeated alliances in market entry. I study these questions in the context of the U.S. pharmaceutical industry where there are 15 distinct therapeutic areas. I configure a fine-grained dataset on alliance activities, drug development activities, and patents of firms in the U.S pharmaceutical industry from 1986 to 2019. I find that the cross-market repeated alliance is a salient phenomenon that bears attention. Firms use cross-market repeated alliances in market entry not only to successfully expand their corporate scope, but also to solidify their existing collaborations in other product markets. Cross-market repeated alliance is also a more efficient way to innovate compared to new partner alliance. These findings highlight the importance of relational resources in market entry and extend our understandings on repeated alliances by identifying the product markets of alliances.