Browsing by Subject "Omega-3 fatty acids"

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    Intrapericardial delivery of Omega-3 Polyunsaturated fatty acids
    (2012-08) Rolfes, Christopher David
    The intrapericardial delivery of antiarrhythmic drugs is very promising, with positive results seen in several animal models to date. The primary purpose of this thesis is to evaluate the efficacies of antiarrhythmic therapies delivered to the pericardial space so as to reduce susceptibility to arrhythmias during cardiothoracic procedures. To accomplish this, a swine model of localized therapy delivery was used to treat intraoperative atrial fibrillation, using metoprolol and omega-3 polyunsaturated fatty acids. Metoprolol administered to the pericardial space had minimal effect on atrial fibrillation or atrial contractility, but significantly reduced heart rate. Certain formulations of fatty acids reduced atrial fibrillation and improved cardiac function upon reanimation in the Visible Heart
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    Novel studies of fat and nutrient intakes and the risk of human cancers
    (2014-05) Ainslie-Waldman, Cheryl Elaine
    Three unique human studies were conducted to explore the relationship between nutritional factors and cancer. In vivo lipid peroxidation was compared in post-menopausal women following a low-fat diet or a low-fat diet supplemented with 3% of energy from omega-3 fatty acids; the latter diet significantly increased in vivo lipid peroxidation. In the second study, a urinary biomarker of indole-3-carbinol exposure from cruciferous vegetable intake was validated in a crossover feeding study. Finally, the associations between dietary fish, fat, and antioxidant intakes and the risk of gastric cancer were evaluated in the large prospective cohort of the Singapore Chinese Health Study. Although, there were no significant associations with fish or fat, coffee intake significantly decreased the risk of gastric cancer among Singapore Chinese women.