Browsing by Subject "Nicotine Use"

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    Data Related to Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use
    (2019-01-16) Liu, Mengzhen; Jiang, Yu; Wedow, Robbee; Li, Yue; Brazel, David M; Chen, Fang; Datta, Gargi; Davila-Velderrain, Jose; McGuire, Daniel; Tian, Chao; Zhan, Xiaowei; 23andMe Research Team; HUNT All-In Psychiatry; Choquet, Hélène; Docherty, Anna R; Faul, Jessica D; Foerster, Johanna R; Fritsche, Lars G; Gabrielsen, Maiken Elvestad; Gordon, Scott D; Haessler, Jeffrey; Hottenga, Jouke-Jan; Huang, Hongyan; Jang, Seon-Kyeong; Jansen, Philip R; Ling, Yueh; Mägi, Reedik; Matoba, Nana; McMahon, George; Mulas, Antonella; Orrù, Valeria; Palviainen, Teemu; Pandit, Anita; Reginsson, Gunnar W, Skogholt, Anne Heidi; Smith, Jennifer A; Taylor, Amy E; Turman, Constance; Willemsen, Gonneke; Young, Hannah; Young, Kendra A; Zajac, Gregory J M; Zhao, Wei; Zhou, Wei; Bjornsdottir, Gyda; Boardman, Jason D; Boehnke, Michael; Boomsma, Dorret I; Chen, Chu; Cucca, Francesco; Davies, Gareth E; Eaton, Charles B; Ehringer, Marissa A; Esko, Tõnu; Fiorillo, Edoardo; Gillespie, Nathan A; Gudbjartsson, Daniel F; Haller, Toomas; Harris, Kathleen Mullan; Heath, Andrew C; Hewitt, John K; Hickie, Ian B; Hokanson, John E; Hopfer, Christian J; Hunter, David J; Iacono, William G; Johnson, Eric O; Kamatani, Yoichiro; Kardia, Sharon L. R; Keller, Matthew C; Kellis, Manolis; Kooperberg, Charles; Kraft, Peter; Krauter, Kenneth S; Laakso, Markku; Lind, Penelope A; Loukola, Anu; Lutz, Sharon M; Madden, Pamela A F; Martin, Nicholas G; McGue, Matt; McQueen, Matthew B; Medland, Sarah E; Metspalu, Andres; Mohlke, Karen L; Nielsen, Jonas B; Okada, Yukinori; Peters, Ulrike; Polderman, Tinca J C; Posthuma, Danielle; Reiner, Alexander P; Rice, John P; Rimm, Eric; Rose, Richard J; Runarsdottir, Valgerdur; Stallings, Michael C; Stančáková, Alena; Stefansson, Hreinn; Thai, Khanh K; Tindle, Hilary A; Tyrfingsson, Thorarinn; Wall, Tamara L; Weir, David R; Weisner, Constance; Whitfield, John B; Winsvold, Bendik Slagsvold; Yin, Jie; Zuccolo, Luisa; Bierut, Laura J; Hveem, Kristian; Lee, James J; Munafò, Marcus R; Saccone, Nancy L; Willer, Cristen J; Cornelis, Marilyn C; David, Sean P; Hinds, David A; Jorgenson, Eric; Kaprio, Jaakko; Stitzel, Jerry A; Stefansson, Kari; Thorgeirsson, Thorgeir E; Abecasis, Gonçalo; Liu Dajiang J; Vrieze Scott; liu00282@umn.edu; Liu, Mengzhen
    We conducted a meta-analysis of over 30 genome wide association studies (GWAS) in over 1.2 million participants with European ancestry on nicotine and substance use. Specifically, we targeted different stages and kinds of substance use from initiation (smoking initiation and age of regular smoking initiation) to regular use (drinks per week and cigarettes per day) to cessation (smoking cessation). The GWAS included have all been imputed to Haplotype Reference Consortium, 1000 Genomes or a combination including more specific reference panels. The studies are then meta-analyzed using sample size, allele frequencies and the imputation quality score as weight. Here we present the final set of filtered meta-analysis summary statistics as presented in the paper (https://doi.org/10.1038/s41588-018-0307-5) excluding 23andMe. As per requirement and to ease dissemination of our results for other scientific endeavors, we are sharing our results here to facilitate downloading.
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    Data Related to Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci
    (2019-02-04) GSCAN; Consortium for Genetics of Smoking Behaviour; CHD Exome+ consortium; erzurumlumesut@gmail.com; Erzurumluoglu, A. Mesut; Consortium for Genetics of Smoking Behaviour; GSCAN consortium; CHDExome+ consortium
    Smoking is a major heritable and modifiable risk factor for many diseases, including cancer, common respiratory disorders and cardiovascular diseases. We tested up to 235,116 single nucleotide variants (SNVs) on the exome-array for association with smoking initiation, cigarettes per day, pack-years, and smoking cessation in a fixed effects meta-analysis of up to 61 studies (up to 346,813 participants). SNV-trait associations with P < 5 × 10−8 in either analysis were taken forward for replication in up to 275,596 independent participants from UK Biobank. Lastly, a meta-analysis of the discovery and replication studies was performed. These novel loci will facilitate understanding the genetic aetiology of smoking behaviour and may lead to the identification of potential drug targets for smoking prevention and/or cessation.