Browsing by Subject "Energy balance"
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Item Exercise, neuropeptides and the hypothalamic regulation of appetite and energy balance(2014-05) Noble, Emily ElizabethThis dissertation is focused on mechanisms involved in the central regulation of appetite, with particular focus on interventions affecting two specific hypothalamic nuclei involved in feeding and energy balance, the ventromedial hypothalamic (VMN) and paraventricular nuclei (PVN). The purpose of these investigations was to identify promising areas of intervention on brain mechanisms involved in the etiology of obesity. First I sought to determine whether exercise dynamically modifies the brain to promote negative energy balance via altering homeostatic appetitive responses. A thorough literature review was performed, which led to the conclusion that, particularly during obesity, aerobic exercise may promote negative energy balance via paradoxically reducing caloric intake despite the increased energy demands of exercise. I then performed a literature review to investigate one particular factor which I believe has promising relevance for how exercise may alter the structure or activity of appetitive regions in the hypothalamus, brain-derived neurotrophic factor (BDNF). In the hypothalamus, BDNF and its receptor, tropomyosin-related kinase B (trkB), are extensively expressed in areas associated with feeding and metabolism, and have been demonstrated to inhibit food intake and increase energy expenditure in both the PVN and VMN, leading to negative energy balance. Furthermore, BDNF via its receptor trkB has a known role in promoting synaptic plasticity and synaptogenesis. Since exercise has been shown to promote sustained alterations in appetite regulation toward maintenance of a leaner phenotype, I hypothesized that exercise-induced feeding reductions are associated with elevated BDNF and trkB in appetite related areas of the hypothalamus. Using Sprague-Dawley rats, I show that over an eight-week period cumulative food intake is reduced in exercising animals compared with sedentary controls, leading to an overall negative energy balance. I report that during the early stages of exercise training, PVN BDNF is elevated in relationship to the amount of running performed by the animals. I did not observe significant changes in BDNF at the eight-week time point, suggesting that exercise may result in early plasticity changes in the PVN, which may alter the function or responsiveness of the PVN during the long-term. In addition to BDNF, I measured trkB receptor in the PVN and surrounding area. I report discovery of trkB immunoreactive fibers surrounding the PVN that have not been previously described in the literature. Quantification of the density of trkB immunoreactive fibers in animals subjected to either volitional or forced running paradigms indicated that volitional running was associated with a reduction in fiber density compared with forced exercise. The second portion of this dissertation focuses on the effects of oxytocin in the VMN on energy balance. Oxytocin, specifically produced in the PVN, has been shown previously to be essential to maintaining energy balance. Currently, literature related to oxytocin is focused on either hindbrain effects of oxytocin on energy balance, or relies on intra cerebroventricular injections, which provide no information about potential sites of oxytocin forebrain effects. Using site-specific VMN injections, I demonstrate for the first time that oxytocin reduces feeding and increases both activity and energy expenditure in this forebrain site. These data are relevant to understanding mechanisms by which oxytocin reduces feeding, and provides insight into the role of oxytocin in the central regulation of energy balance.Item Generalizations for Insolation and Albedo to Adapt an Energy Balance Model to Other Planets(2019-05) Nadeau, AliceInterest in modeling the climates of other planets has been stimulated by observations of the Pluto-Charon system and seven Earth-sized planets orbiting the nearby star TRAPPIST-1. Furthermore, as of March 2019, over four thousand planets outside of our solar system have been discovered. Scientists are interested in what these planets might be like and if they could support life as we know it, but there is very little empirical information that they can collect in order to learn more about them. For this reason, scientists must rely on models to study climate on these planets. Because so little is known about our planetary neighbors compared to Earth, and even less is known about planets outside of our solar system, it is hard to faithfully model their climates using complex models such as such as the class of models referred to as General Circulation Models (GCMs). Instead, conceptual climate models may be preferred because the small number of state variables and parameters (relative to GCMs) make it easier to quantify possible behaviors of the system. Adapting well known conceptual models for Earth to extraterrestrial and extrasolar planets raises issues whose solutions draw from the fields of celestial mechanics, harmonic analysis and nonsmooth systems. This work focuses on a main component of conceptual climate models---incoming radiation absorbed by the planet---and the mathematical considerations for and implications of adapting this component to planets other than Earth. We generalize both the distribution of insolation and location of different albedos on the planet's surface. We find that the insolation distribution for slowly rotating planets approaches a rapid rotation distribution like the reciprocal of the rotation rate. Additionally, we show that it is possible to have stable, asymmetric configurations of ice in an energy balance model of Pluto.