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Browsing by Subject "Dogs"

Now showing 1 - 3 of 3
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    Comparison of individually-adjusted heparin versus ultra low-dose aspirin for prevention of thromboemboli in immune-mediated hemolytic anemia in dogs and the safety of ultrasoud-guided fine needle aspiration of the feline pancreas: a case-control Study
    (2014-06) Crain, Sarah Kathleen
    The following thesis is a compilation of the clinical studies designed and performed over a 3-year period at the University of Minnesota College of Veterinary Medicine. The studies, which include a prospective, randomized clinical trial and a retrospective case-controlled study, are unrelated to each other in subject matter, but both proved to be challenging in their own way, and had a lot to teach as far as the challenges and benefits unique to each type of clinical trial. The chapters first include a review of canine autoimmune hemolytic anemia, which provided significant insight into the common types of studies performed in veterinary medicine as well as provides background on a complex and interesting disease. The second and third chapters detail the studies performed, as well as discuss the specific challenges, shortcomings, and learning issues presented with each study. Despite careful planning and anticipation of the potential issues that would be encountered, each study was imperfect in its own way. Performing these studies was a very valuable way to learn about the challenges of study design, data collection, and data evaluation.
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    The Development and use of canine adipose derived stromal and progenitor cells to treat osteoarthritis
    (2013-12) Kiefer, Kristina M.
    We evaluated the viability of canine adipose derived stromal cells (ASC) in the presence of osteoarthritic joint fluid, determining that exposure to osteoarthritic joint fluid is more cytotoxic than exposure to normal synovial fluid. We demonstrated that diluting the joint fluid diminishes the severity of this effect. We have demonstrated that a stromal vascular fraction (SVF) preparation of ASCs is phenotypically different from cultured ASCs, having a greater expression of proinflammatory mediator (IL-1β (interleukin-1 beta), COX-2 (cyclooxygenase-2)) and anti-inflammatory mediators (IL-1ra (interleukin-1 receptor antagonist), TIMP-2 (tissue inhibitor metalloproteinase-2) mRNA levels than cultured cells, and greater variability in expression of cell surface markers (MHCI, MHCII, CD90, CD34, CD44 and CD45). We evaluated multiple types of culture media, and found that there is some variation in the previous mentioned markers and mediators, but not a significant difference. Consistent tri-lineage differentiation of ASCs appeared to differ amongst different media types. We concluded that media should be selected according to a phenotypic profile that would be beneficial for the disease the ASC therapy is targeting. We assessed in vivo safety and efficacy of canine autologous SVF and allogeneic ASC therapy in dogs diagnosed with osteoarthritis secondary to a medial coronoid process in the elbow, utilizing objective outcome measures, including ground reaction forces (GRF) and delayed gadolinium enhanced magnetic resonance imaging of cartilage (dGEMRIC). We found no significant deleterious side effects with either therapy, and have produced support for the use of allogeneic ASC therapy.
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    “This dog means Life”: making interspecies relations at an assistance dog agency.
    (2011-05) Edminster, Avigdor
    My ethnographic informants at an assistance dog agency say that dogs and humans can read each others' minds, have saved each others' lives, hear for one another, and are family and business partners. These clients, assistance dogs, staff, and volunteers have uniquely intimate, interdependent interspecies relationships despite the power of absolutist distinctions between humans and other animals. I explore how my informants understand and create shared and unshared dimensions between them as they also navigate and change ideas about the family, workplace, and larger society. Explored in tandem these relationships and cultural domains illuminate the anxieties, ambiguities, and securities experienced in both. Central to this project are the ways that shared embodied relational meaning emerges as my informants make meaningful lives together.