Browsing by Subject "Carbon monoxide"
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Item Gonzalez 2021 tagged CO model archive(2021-04-19) Millet, Dylan B.; Gonzalez, Andres; Yu, Xueying; dbm@umn.edu; Millet, Dylan B.; University of Minnesota Atmospheric Chemistry GroupThis archive contains model code, input files, and simulation results for atmospheric carbon monoxide (CO) posted in association with the referenced paper.Item An On-Board Emissions and Performance Measurement System (OEPMS) for Measuring Carbon Monoxide Emission During Cold Starting(Minnesota Department of Transportation, 1999-05) Johnson, Jason P.; Kittelson, David B.This report describes the results of a project to develop an on-board emissions and performance measurement system (OEPMS) for the quantification of carbon monoxide (CO) emissions. Researchers measured emissions from a 1990, 2.5 liter TBI engine passenger automobile over a typical suburb-to-city commute in the Minneapolis/St. Paul metropolitan area. As a test of the OEPMS, researchers measured CO emissions during cold weather cold starts and commutes at temperatures characteristic of the area's winter weather. Open-loop and closed-loop emissions of CO were measured and compared. Additionally, the effectiveness of magnetic-type block heaters was examined. Tests with the OEPMS provided a wide range of results. The OEPMS proved very durable and easily adaptable for a wide variety of testing. The OEPMS holds promise for future research into fuels, emissions reducing technologies, regulations, and commute habits in real world situations.Item Regulation and Effects of Heme-Oxygenase-1 Expression in Chronic Inflammation.(2010-06) Beckman, Joan DeniseHeme oxygenase-1 (HO-1) enzyme plays critical role in metabolizing the excess heme generated during hemolysis in pathological conditions, such as sickle cell disease. We and others have previously demonstrated that during chronic intravascular hemolysis the expression of HO-1 protein is not sufficient to reduce the oxidative burden of free heme in the vasculature, leading to oxidative stress and vascular inflammation. This proposal examined two areas critical to the understanding of HO-1 expression and function during inflammation: the role of post-transcriptional regulation in control of protein expression and the importance of its by-product carbon monoxide (CO) in mediating anti-inflammatory, anti-apoptotic effects. The research utilized a murine sickle model which has perturbations of heme catabolism leading to oxidative stress and inflammation. Studies in this model will test whether HO-1, or its by-products, can therapeutically alter the natural history of sickle cell disease. In addition, cell culture models in which heme levels are controlled were used to explore microRNA regulation of heme oxygenase-1 (HO-1) expression. Combined these experimental endeavors aim to identify new aspects of HO-1 research.