Between Dec 19, 2024 and Jan 2, 2025, datasets can be submitted to DRUM but will not be processed until after the break. Staff will not be available to answer email during this period, and will not be able to provide DOIs until after Jan 2. If you are in need of a DOI during this period, consider Dryad or OpenICPSR. Submission responses to the UDC may also be delayed during this time.

Browsing by Subject "Bisphenol A"

Now showing 1 - 2 of 2
  • Thumbnail Image
    Item
    Bisphenol A, Diet and Obesity: Exposure Measurement and the Relationship Between Diet and Bisphenol A
    (2014-01) Oppeneer, Sarah
    Diet is considered the primary source of BPA exposure, due to the use of BPA in polycarbonate plastics and epoxy resins used in food packaging. Existing human research has major limitations and the cost of serum and urinary BPA assay remains a challenge in evaluating BPA exposure and chronic disease outcomes. Despite the fact that diet is a vehicle for BPA exposure, few studies have considered whether dietary composition alters the toxicokinetics of BPA. Epidemiological studies have also not addressed diet as a potential confounder or effect modifier even though diet is associated with both disease risk and BPA exposure. The Urinary Biomarkers of Dietary Intake (UB-Diet Study) was developed to evaluate the feasibility of using questions that target intake of known dietary sources of BPA to estimate BPA exposure. Predicted BPA exposure levels from the BPA exposure assessment module (BEAM) were compared to multiple spot urine samples. Food records were also collected on the days that urine samples were collected to further evaluate the relationship between diet and urinary BPA levels. Reported macronutrient and food group servings were compared to urinary BPA levels. The BEAM data was not able to accurately predict participants' urinary BPA levels. Recent canned food intake was associated with urinary BPA levels, but only explained approximately one-fifth of the variability in urinary BPA levels and several participants who reported consuming no canned foods had high urinary BPA levels. The study findings suggest that BPA levels may be positively associated with higher caloric and fiber intake, and intakes of vegetables, refined grains and red meats, and inversely associated with total fat intake. More research is needed to characterize sources of BPA exposure, to evaluate the role of diet in the toxicokinetics of BPA and to determine if chronic low level BPA exposure poses any health risk.
  • Thumbnail Image
    Item
    Bisphenol A: Should You Be Concerned?
    (2008-04-08) Tweet, Marysia Susan
    Bisphenol A (BPA) is a raw material primarily used as a monomer in polycarbonate and epoxy resin production. Industry produces more than 6 billion pounds of BPA each year, and it has been used commercially for ~50 years. Polycarbonates are used in infant bottles, plastic dinnerware and storageware, and therefore BPA may leach into human food. According to the Centers for Disease Control and Prevention (CDC), about 95% of Americans contain BPA in their blood. Recent concerns regard the effects of low exposure of BPA on human development and reproduction stemming from experimental evidence that BPA may weakly bind to estrogen receptors. The US NTP held an expert panel Aug 2007 reviewing 500 studies about BPA. The panel expressed “some” concerns that exposure causes neural and behavioral effects in infants and children and “minimal” concerns that it causes early puberty. No major health risks were found. A final statement is pending. The absolute decision regarding the effects of BPA on humans remains debated and is subject for continued studies.