Browsing by Subject "Aspirin"
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Item Carotid Stenosis: Information for Patients(2010-07-29) Briese, NickCarotid stenosis increases your risk of stroke and transient ischemic attack (TIA). Aspirin, along with control of blood pressure and cholesterol and smoking cessation, can help lower the risk of stroke. This pamphlet briefly describes carotid stenosis, risk factors for carotid stenosis, and steps that patients can take to reduce their risk for carotid stenosis and the problems that come with it.Item Coumadin or aspirin use in patients with Age-Related Macular Degeneration(2012-04-10) Hillard, ChristopherItem Inflammatory processes and risk of cancer: epidemiological research.(2010-05) Prizment, Anna EChronic inflammation has been implicated in cancer etiology but it is unclear whether inflammation causes cancer or results from tumor growth. To address these questions, we examined three hypotheses about the role of inflammation in incident cancers in large prospective cohorts. In the first manuscript, we hypothesized that increased levels of circulating acute-phase reactants, which are markers of inflammation, such as white blood cells, fibrinogen, factor VIII, von Willebrand factor, and C-reactive protein (CRP) (positive reactants) and decreased levels of albumin (a negative reactant) are associated with increased risk of subsequent colorectal cancer (CRC) in a prospective cohort - ARIC. After multivariate adjustment, there were statistically significant associations of CRC risk with two individual markers and a summary inflammation Z- score. For the highest versus lowest quartile, hazard ratios HR (95% confidence interval) were 1.50 (95%CI, 1.05; 2.15) for fibrinogen (p-trend across quartiles was 0.03); 1.97 (95%CI, 1.13; 3.43) for CRP (p-trend=0.02); and 1.65 (95%CI, 1.15; 2.35) for Z-score (p-trend=0.01). To our knowledge, no previous studies have examined a summary inflammation score in relation to incident cancers. The second manuscript hypothesized that the frequency of NSAIDs use was inversely associated with incident ovarian and endometrial cancers in the IWHS cohort of elderly women. We found that compared to women who reported no use of aspirin, the multivariate-adjusted HRs of ovarian cancer for those who used aspirin less than 2, 2-5 times, and 6 or more times per week were 0.83, 0.77 and 0.61, respectively (p-trend=0.04). We did not observe associations between non-aspirin NSAIDs use and ovarian cancer risk or between any NSAIDs use and endometrial cancer risk. The third manuscript examined whether elderly women (65+) suffering from an inflammatory autoimmune disease - psoriasis - have an increased risk of total, breast, lung, or colon cancers in the IWHS cohort linked to Medicare. We observed an association between psoriasis and colon cancer risk: multivariate-adjusted HR=1.57 (95%CI, 1.02; 2.42) for those with versus without psoriasis. This association was stronger for severe psoriasis. Findings from these studies give further support to the hypothesis that chronic inflammation may play a role in colorectal and ovarian carcinogenesis.Item Low dose aspirin therapy, can it help prevent heart attacks and stroke in you?(2012-04-10) Radke, PhillipItem Preventing Stroke in Patients with Atrial Fibrillation(2012-07-24) Petersen, ElizabethItem Should I take a blood thinner after a stroke?(2012-04-10) Vlasak, AndreaItem Stroke or TIA prevention in the setting of new onset atrial fibrillation.(2010-07-29) Surowiecka, MariaAtrial fibrillation is an irregular heartbeat that can lead to blood clots in the heart. These clots can dislodge and travel to the brain, resulting in stroke and possible death. This pamphlet describes how patients with atrial fibrillation, especially those with a prior history of stroke or mini-stroke (TIA), should be on anticoagulation medication with warfarin to prevent clot formation.Item Which NSAID Pain Relievers Should I Use If I Have Heart Disease Risk?(2009-08-20) Bohman, J. KyleCommon pain relievers including NSAIDs, Aspirin and COX-2 inhibitors have been shown to have varying degrees of cardiac disease risk and gastritis risk. The choice between pain relievers depends on an individual’s risk factors and tolerance of side effects.