Browsing by Author "Largaespada, David"
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Item Inhibition of NRAS signaling in an in vitro model of human MLL-AF9/NRAS^G12V acute myeloid leukemia(2011-09-16) Hazen, Katherine; Eckfeldt, Craig; Largaespada, DavidObjective and Hypothesis: Investigate the therapeutic potential of NRAS-targeted therapy in the human MLL-AF9 and NRASG12V-driven AML cell line THP-1 using shRNA and small molecule inhibitors. We hypothesize that inhibition of NRAS using shRNA and inhibition of PI3K/AKT/mTOR and RAF/MEK/ERK pathways using small molecule inhibitors will lead to leukemic cell death.Item Pathway Analysis of Major Genes Affecting Osteosarcoma Metastasis(2021) Makaram, Aditi; Sverak, Helena; Largaespada, DavidItem sgRNA Design and Optimization in Immortalized Human Schwann Cells(2018-10-12) Steiger, Ryan, J; Nikrad, Julia; Williams, Kyle; Larsson, Alex; Largaespada, DavidItem Validation of Candidate Drivers of Osteosarcomagenesis with High-Throughput In Vitro Screening(2018) Dunnell, Justin; Slipek, Nicholas; Varshney, Jyotika; Temiz, Nuri; Shafer, Paul; Knudson, Puggy; Osborne, John; Peterson, Joe; Kurata, Morito; Largaespada, David