Browsing by Author "Hedberg, Jack"
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Item Abnormal Accumulation of Reactive Oxygen Species from Pitx2 Mutation Could Cause HLHS(2017) Naik, Anant; Puram, Vikram; Hedberg, JackHypoplastic Left Heart Syndrome (HLHS) is a highly rare congenital heart defect in which the left side of the heart is critically underdeveloped. At the cellular level, changes in ventricular structure include myocyte growth and myocyte apoptosis. Ultimately, this progressive remodeling can result in heart failure and, in HLHS, premature death. Recent progress in understanding these mechanisms of myocardial remodeling has led to evidence that reactive oxygen species (ROS) and oxidative stress play a central role in regulating the phenotype of cardiac myocytes. We hypothesize that ROS-mediated developmental destabilization due to pitx2 dysfunction in the left ventricle, coupled with the low and high strain placed on the interventricular septum (IV) and left ventricular (LV) wall during cardiac contraction, respectively, causes HLHS. Genetic tests of mouse models and in vitro studies of cardiomyocytes confirm this proposed progression. Further investigation could open the door to curative gene therapy and prevent many years of suffering and complications with surgical procedures for affected infantsItem The Undergraduate Surgery Interest Group (USIG): A New Venue for Premedical Student Exposure to the Field of Surgery(Journal of the American College of Surgeons, 2016-10) Hedberg, JackEarly exposure to the field of surgery through workshops, lectures, and mentors may bolster and prolong interest in surgical careers for undergraduate students. An Undergraduate Surgery Interest Group (USIG) was started through the initiative of students, seeking to create more opportunities through which younger students could develop and explore their motivations for advancing toward surgical practices. This USIG has received advisorship, resources, and support from the University of Minnesota Medical School Department of Surgery. A group of students may work with the medical school and student government to develop a constitution defining the objectives and structure of the group, as well as create officer positions. Coordination with an advisor is recommended to aid navigation and networking within the medical school necessary for resources, events, and speakers. The group may then be publicized through social media, flyers, and various departments within the university to gain membership and participation. A USIG was created by a board of five undergraduate students under mentorship within the medical school. Each board member has a well-defined role and oversight by a USIG president. Weekly board meetings are held to coordinate bi-weekly events, which include surgical technique workshops, tours of medical labs, exposure to next-generation biomedical engineering devices, and discussions involving the history of surgery. This USIG was created in Fall 2015 and now has 260 active undergraduate participants. A Facebook page has been used to publicize events and workshops, currently with about 200 ‘Likes’. Short-term success of the group is routinely evaluated through member surveys and post-event questionnaires, and long-term impacts of the group will be evaluated through physicians citing the USIG as influential to their career. USIG provides unique opportunities for undergraduates to gain exposure and interest in the surgical field while promoting long-term commitment. In turn, advisers may discover students with valuable qualities, while medical students gain teaching opportunities which better prepare them for clinical rotations in surgery.