Browsing by Author "Dudley, Richard"

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    Chemical Stability of Hydrocortisone in Topical Preparation in Proprietary VersaProTM Cream Base
    (University of Minnesota, College of Pharmacy, 2011) Sarkar, Arindam Basu; Dudley, Richard; Melethil, Srikumaran; Speidel, Jonathon; Bhatt, Gopalkumar Markandakumar
    The United States Pharmacopeia-National Formulary (USP-NF) suggests beyond use dating ((BUD) for compounded topical preparations containing active pharmaceutical ingredients (API) [1]. The beyond the use dates of the preparations are based on the conservative and empirical guidelines of USP 795. Hydrocortisone (HC) content compounded in the VersaPro™ base cream was quantified using a HPLC method at time zero and after 30 and 60 days of storage at both room temperature and 4℃. The analysis suggests that the compounded preparations retain > 95% of the stated initial potency of HC regardless of storage conditions. Thus HC creams prepared in VersaPro™ cream base can be safely assigned a beyond the use date of two months when stored at room temperature.