Histone deacetylases (HDACs) are negative regulators of transcription.
Endochondral bone formation including chrondocyte and osteoblast maturation is
regulated by HDACs. Very little is known about the role HDACs play in osteoclast
differentiation. This study found that suppression of HDAC3 expression represses
osteoclastogenesis, while osteoclasts suppressed for HDAC7 expression had accelerated
differentiation compared to control cells.
University of Minnesota M.S. thesis. June 2010. Major: Dentistry. Advisor: Dr. Kim Mansky. 1 computer file (PDF); vi, 21 pages, appendices I-III. Ill. (some col.)
Romsa, Amanda Marie.
Histone deacetylase 3 and histone deacetylase 7 Have opposite effects on osteoclast differentiation..
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