The progressive increase of heat dissipation from modern electronics requires more and more powerful cooling systems. Various cooling technologies have been developed such as liquid cooling, micro-channel cooling, and active cooling. The present study focuses on applying a unique device called a synthetic jet to cool electronics. A synthetic jet is able to generate an unsteady flow with a simple structure that makes it effective in convective heat transfer. This study provides both practical and fundamental view of synthetic jets in the application of electronics cooling. A mock-up synthetic jet is fabricated to study heat transfer and fluid mechanics of synthetic jet cooling. The scaled synthetic jet is geometrically and dynamically similar to the actual jet. The heat transfer performance characteristics of a synthetic jet impinging on a fin are tested with different operating frequencies and with different orifice shapes. Flow visualizations and detail flow field measurements of the impinging synthetic jet flow are documented to support the heat transfer experiment. The optimized parameters obtained from the scaled experiment are applied to the actual synthetic jet design. The actual synthetic jet is realized using a piezoelectric stack and applied on a cooling system based on a full-sized heat sink module. The cooling performance of the whole system is documented. The noise characteristics of the actual synthetic jet is tested and analyzed. A muffler with optimized parameters is found and used for noise reduction. Numerical simulation is used to find the optimal design for the synthetic jets. The computation is realized by the commercial software ANSYS Fluent. The numerical model is verified by comparing the computational results with experimental results. A parametric study of heat transfer performance of synthetic jet cooling is documented.