Bis-phenoxides as Ligands for Ti-mediated Hydroamination and Pyrrole Formation Catalysis

Abstract

This thesis covers the development of a new aryl-linked bis-phenoxide ligand, its use in synthesis of Ti complexes, and the catalytic utility of those complexes for hydroamination and pyrrole synthesis. Chapter 1 outlines the literature background for Ti-catalyzed hydroamination and pyrrole synthesis. Chapter 2 describes the synthesis of the bis-phenoxide ligand, its use in Ti-complexes, and the ability of those complexes to catalyze hydroamination reactions. Chapter 3 details a transfer hydrogenation/pyrrole synthesis reactions using the same Ti-complexes. Chapter 4 discusses efforts to isolate a low-valent species using the aryl-linked bis-phenoxide ligand and improve on the ligand via extension of the center aryl linker.