Lorsung, Ethan2022-11-142022-11-142022-08https://hdl.handle.net/11299/243035University of Minnesota M.S. thesis. 2022. Major: Integrated Biosciences. Advisor: Ruifeng Cao. 1 computer file (PDF); 82 pages.Autism spectrum disorders (ASDs) are a spectrum of neurodevelopmental disorders characterized by impaired social interaction and communication, as well as stereotyped and repetitive behaviors. ASDs affect nearly 2% of the United States child population and the worldwide prevalence has dramatically increased in recent years. The etiology is not clear but ASD is thought to be caused by a combination of intrinsic and extrinsic factors. Circadian rhythms are the ∼24 h rhythms driven by the endogenous biological clock, and they are found in a variety of physiological processes. Growing evidence from basic and clinical studies suggest that the dysfunction of the circadian timing system may be associated with ASD and its pathogenesis. Here I review the findings that link circadian dysfunctions to ASD in both experimental and clinical studies, then I report novel research furthering the relationship between the core circadian gene Bmal1 and ASD. I first introduce the organization of the circadian system and ASD. Next, I review physiological indicators of circadian rhythms that are found disrupted in ASD individuals, including sleep–wake cycles, melatonin, cortisol, and serotonin. I then review evidence in epidemiology, human genetics, and biochemistry that indicates underlying associations between circadian regulation and the pathogenesis of ASD. Finally, I design and report findings of my original basic research, including pervasive abnormalities in the developing mouse cerebellum and social deficits as a result of deletion of the core circadian component Bmal1. In conclusion, I propose that understanding the functional importance of the circadian clock in normal and aberrant neurodevelopmental processes may provide a novel perspective to tackle ASD, and clinical treatments for ASD individuals should comprise an integrative approach considering the dynamics of daily rhythms in physical, mental, and social processes.enAutism Spectrum DisorderCerebellumCircadian RhythmThesis or Dissertation