Romsa, Amanda Marie2010-08-242010-08-242010-06https://hdl.handle.net/11299/93344University of Minnesota M.S. thesis. June 2010. Major: Dentistry. Advisor: Dr. Kim Mansky. 1 computer file (PDF); vi, 21 pages, appendices I-III. Ill. (some col.)Histone deacetylases (HDACs) are negative regulators of transcription. Endochondral bone formation including chrondocyte and osteoblast maturation is regulated by HDACs. Very little is known about the role HDACs play in osteoclast differentiation. This study found that suppression of HDAC3 expression represses osteoclastogenesis, while osteoclasts suppressed for HDAC7 expression had accelerated differentiation compared to control cells.en-USHistone deacetylases (HDACs)Osteoblast maturationOsteoclastogenesisControl cellsDentistryThesis or Dissertation