Krasutsky, Pavel A2018-11-272018-11-271999-07Project No. 5599520https://hdl.handle.net/11299/200966Natural Resourses Research Institute, University of Minnesota Duluth; Prepared for: Minnesota Technology, Inc.; Reporting Period: July 1, 1998 -June 30, 1999.The overall goal of this project to Utilize Chemicals Isolated from Birch Bark as a Therapeutic Treatment against Pathogenic Herpes Virus. More specifically the goal of the proposed investigation will be to synthesize 45-50 betulin/ allobetulin prodrugs of increased hydrophiloic character, confirm the structure properties of each new compound and perform the necessary biological testing to identify the top 2-3 candidates to move forward the clinical trials.enPathogenic herpes virusWhite birch barkHerpes simplex virus (HSV)Antiviral activityFinal progress reportBetulinBetulla speciesNatural Resources Research InstituteUniversity of Minnesota DuluthTechnical Report