Arnold, Susan APluhar, G. ElizabethAbrahante Llorens, Juan E2024-11-152024-11-152024-11-15https://hdl.handle.net/11299/267779There are two data files that contain the raw gene expression data for French bulldogs, boxers, and Boston terriers pre- and post-immunotherapy treatment. One data file contains French bulldog paired RNA sequencing data. These data were used to assess transcriptomic changes in French bulldogs post-treatment compared to pre-treatment. The other data file contains boxer and Boston terrier paired RNA sequencing data. These data were used to assess transcriptomic changes in boxers and Boston terriers post-treatment compared to pre-treatment. Samples consist of pre-treatment samples, which were obtained at the time of surgical resection of high grade gliomas, and post-treatment samples, which were obtained from whole brains collected after death. Immunotherapy treatment consisted of a combination of autologous tumor lysate therapy and an immune checkpoint inhibitor.These files contain the raw data for bulk RNA sequencing performed on canine high grade glioma tumor samples. These samples were obtained from three breeds of dogs: French bulldogs, boxers, and Boston terriers. All dogs were enrolled in immunotherapy clinical trials within the University of Minnesota Canine Brain Tumor Program. They were obtained from two different time points relative to treatment: pre-treatment and post-treatment. Treatment consisted of surgical resection and immunotherapy. The purpose of these data are to provide a comprehensive profile of how canine high grade glioma transcriptomes change in response to immunotherapy treatment, and to determine if there are breed-associated changes in differential gene expression.Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/canine gliomacanine brain tumortranscriptomicsRNASeqimmunotherapyDataset