Styczynski Snyder, Angela Lynn2014-01-092014-01-092011-11https://hdl.handle.net/11299/162262University of Minnesota Ph.D dissertation. Ph.D. November 2011. Major: Biomedical Engineering. Advisor: Michael Garwood. 1 computer file (PDF); vi, 96 pages.MRI of the body at 7 T has become possible only very recently. High fields bring the advantages of increased signal to noise ratio, resolution gains, faster image acquisition through better parallel imaging, improved and novel types of contrast, and greater spectral dispersion. There are many obstacles to be faced in the advancement to 7 T including field inhomogeneities, transmit inhomogeneities, and increased RF-absorption risk. Inhomogeneous B1+ is possibly the most significant obstacle currently facing 7 T body imaging in consistently producing clinical-quality images. In this work, the first demonstrations of MR imaging and spectroscopy (MRS) of the liver at 7 T are presented and evaluated with special attention given to parallel imaging. Also presented here is the first demonstration of imaging of the uterus at 7 T with particular emphasis on contrast between uterine layers. A comparison was done between 3 T and 7 T, and relaxation rates were mapped including higher rotating frame relaxations.SWIRLY (spatiotemporal-encoding with incremental refocusing along a trajectory) is a novel pulse sequence that employs a frequency and amplitude modulated excitation pulse in the presence of sinusoidal gradients to move a region of resonance through space along a spiral trajectory. The signal can be sequentially refocused and acquired in an entirely spatiotemporal manner such that no Fourier Transform is needed for reconstruction. Because each resonance region can be treated entirely independently, this sequence has incredible potential for addressing problems that are inherently spatial in nature, such as B1+ and B0 inhomogeneities.en-US7TB1 inhomogeneityLiverMRISpatiotemporalUterusThesis or Dissertation